Tedizolid in skin and skin structure infections: brave new world?
نویسندگان
چکیده
منابع مشابه
New developments in the management of severe skin and deep skin structure infections – focus on tedizolid
Tedizolid, a novel oxazolidinone, is approved for treatment of acute bacterial skin and skin structure infections (ABSSSIs). Tedizolid offers several potential advantages over current ABSSSI treatment options. First, tedizolid has a prolonged half-life, which allows for once-daily dosing. Second, tedizolid has broad spectrum activity against Gram-positive organisms including methicillin-resista...
متن کاملCritical role of tedizolid in the treatment of acute bacterial skin and skin structure infections
Tedizolid phosphate has high activity against the Gram-positive microorganisms mainly involved in acute bacterial skin and skin structure infections, such as strains of Staphylococcus aureus (including methicillin-resistant S. aureus strains and methicillin-sensitive S. aureus strains), Streptococcus pyogenes, Streptococcus agalactiae, the Streptococcus anginosus group, and Enterococcus faecali...
متن کاملTedizolid phosphate for the management of acute bacterial skin and skin structure infections: safety summary.
The novel oxazolidinone tedizolid phosphate is in late-stage clinical development. In an effort to improve efficacy and safety, the adverse event profile and safety aspects of tedizolid phosphate have been evaluated in several preclinical animal models and through ongoing clinical trials. Early dose-ranging studies demonstrated a favorable overall adverse event profile and low thrombocytopenia ...
متن کاملTedizolid phosphate for the management of acute bacterial skin and skin structure infections: efficacy summary.
The novel oxazolidinone tedizolid phosphate is in late-stage development for acute bacterial skin and skin structure infections (ABSSSIs). Preclinical and phase 1 trials have shown that 200-mg once-daily tedizolid phosphate dosing achieves the appropriate pharmacokinetic goals for optimal antimicrobial effect, and a randomized phase 2 dose-ranging trial confirmed that tedizolid phosphate may be...
متن کاملProfile of tedizolid phosphate and its potential in the treatment of acute bacterial skin and skin structure infections
Tedizolid phosphate is the first once-daily oxazolidinone approved by the United States Food and Drug Administration for the treatment of acute bacterial skin and skin structure infections (ABSSSI). It is more potent in vitro than linezolid against methicillin-resistant Staphylococcus aureus (MRSA) and other gram-positive pathogens causing ABSSSI, even retaining activity against some linezolid-...
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ژورنال
عنوان ژورنال: Expert Opinion on Pharmacotherapy
سال: 2016
ISSN: 1465-6566,1744-7666
DOI: 10.1080/14656566.2016.1244525